The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis

被引：83

作者：

Lolli, F

Mazzanti, B

Pazzagli, M

Peroni, E

Alcaro, MC

Sabatino, G

Lanzillo, R

Morra, VB

Santoro, L

Gasperini, C

Galgani, S

D'Elios, MM

Zipoli, V

Sotgiu, S

Pugliatti, M

Rovero, P

Chelli, M

Papini, AM

机构：

[1] Univ Florence, Dipartimento Sci Neurol & Psichiatriche, Ctr Polivalente, I-50134 Florence, Italy

[2] Univ Florence, Lab Interdipartimentale Chim & Biol Peptidi & Pro, I-50019 Sesto Fiorentino, FI, Italy

[3] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy

[4] CNR, ICCOM, I-50019 Sesto Fiorentino, FI, Italy

[5] CSF srl, I-50124 Florence, Italy

[6] Univ Naples Federico II, Dipartimento Sci Neurol, I-80131 Naples, Italy

[7] Univ Roma, Osped St Camillo Forlanini, Dipartimento Neurosci, I-00152 Rome, Italy

[8] Univ Florence, Dipartimento Med Interna & Immunoallergol, I-50134 Florence, Italy

[9] Univ Sassari, Neurol Clin, I-07100 Sassari, Italy

[10] Univ Florence, Dipartimento Sci Farmaceut, I-50001 Sesto Fiorentino, FI, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 167卷 / 1-2期

关键词：

multiple sclerosis; myelin autoantibodies; glycosylated antigen; diagnosis; B cell; autoimmunity;

D O I：

10.1016/j.jneuroim.2005.05.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Synthetic glycopeptides have the potential to detect antibodies in multiple sclerosis (MS). In the present study, we analyzed the antibodies (IgM class, IgG class and IgG subclasses) to the synthetic glycopeptide CSF114(Glc) in the serum of 186 MS patients, 166 blood donors (BDs), 25 patients affected by meningitis/encephalitis, 41 affected by systemic lupus erythematosus (SLE) and 49 affected by rheumatoid arthritis (RA). The IgM antibody level to CSF114(Glc) was significantly increased in MS patients versus BDs (p<0.001) or versus other autoimmune diseases (SLE or RA, p<0.001). The IgG response was restricted to the subclass IgG2. IgM antibodies to CSF114(Glc) were found in 30% of relapsing/remitting MS patients and, at lower levels, in subjects affected by meningitis/encephalitis. The study of antibodies to CSF114(Glc) is a new, potential immunological marker of MS. (C) 2005 Elsevier B.V.. All rights reserved.

引用

页码：131 / 137

页数：7

共 42 条

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