Human MRP3 transporter:: identification of the 5′-flanking region, genomic organization and alternative splice variants

被引：35

作者：

Fromm, MF

Leake, B

Roden, DM

Wilkinson, GR

Kim, RB

机构：

[1] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Pharmacol, Nashville, TN 37232 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1415卷 / 02期

关键词：

MRP3; multidrug resistance-associated protein; alternative splicing; tissue distribution; intron-exon organization;

D O I：

10.1016/S0005-2736(98)00233-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report the molecular cloning of two splice variants of MRP3 from human liver. In addition, MRP3 genomic organization including the 5'-flanking region and a major portion of the MRP3 intron-exon organization are identified and characterized. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：369 / 374

页数：6

共 18 条

[1] OVEREXPRESSION OF A TRANSPORTER GENE IN A MULTIDRUG-RESISTANT HUMAN LUNG-CANCER CELL-LINE [J].