Germinal center reaction

被引：93

作者：

McHeyzer-Williams, LJ ^{[1
]}

Driver, DJ ^{[1
]}

McHeyzer-Williams, MG ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2001年 / 8卷 / 01期

关键词：

D O I：

10.1097/00062752-200101000-00010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity. The main purpose of the germinal center reaction is the development of B-cell memory through. iterative cycles of somatic antigen receptor diversification and the selection of B cells with receptors of best fit. Recent studies provide insight into the regulation of these complex processes in vivo with new information on the cellular organization of the memory B-cell compartment. (C) 2001 Lippincott Williams & Wilkins, Inc.

引用

页码：52 / 59

页数：8

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