An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application

被引：207

作者：

Chirila, TV

机构：

[1] Univ Western Australia, Ctr Ophthalmol & Vis Sci, Nedlands, WA 6009, Australia

[2] Univ Western Australia, Lions Eye Inst, Nedlands, WA 6009, Australia

来源：

BIOMATERIALS | 2001年 / 22卷 / 24期

关键词：

artificial cornea; porous polymers; PHEMA; hydrophilic sponges; human clinical trials;

D O I：

10.1016/S0142-9612(01)00168-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An overview of the efforts to develop functional polymeric artificial corneas (keratoprostheses) by incorporating a porous skirt is presented. The development of such a device by the author's group using poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels, as a combination of their homogeneous and heterogeneous states, and the rationale of this choice are also discussed. The latest results of the clinical trials with the PHEMA keratoprosthesis in human patients indicate a lower risk of the complications traditionally associated with the implantation of artificial corneas. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3311 / 3317

页数：7

共 78 条

[1] KERATOPROSTHESES - PAST AND PRESENT [J].