QSAR studies on acylated histamine derivatives

被引：16

作者：

Agrawal, VK

Khadikar, PV

机构：

[1] Laxmi Pest & Fumigat Pvt Ltd, Div Res, Indore 452007, India

[2] APS Univ, Dept Chem, Rewa 486003, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0968-0896(01)00147-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

H-3-receptor antagonists activity in terms of -log K-i for a series of acylated histamine derivatives was modeled using topological indices, namely negentropy (N), molecular redundancy (MRI), and valence connectivity index ((m)x(v)) indices. Excellent results were obtained in multiple regression analysis upon the introduction of a dummy parameter (indicator parameter). Consistant increase in R-A(2) value indicated that inspite of observed collinearity the proposed models are significant. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2787 / 2792

页数：6

共 19 条

[1]

[Anonymous], 1949, MATH THEORY COMMUNIC

[2] AUTO-INHIBITION OF BRAIN HISTAMINE-RELEASE MEDIATED BY A NOVEL CLASS (H-3) OF HISTAMINE-RECEPTOR [J].