Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line

被引：27

作者：

Ando, S

Nojima, K

Majima, H

Ishihara, H

Suzuki, M

Furusawa, Y

Yamaguchi, H

Koike, S

Ando, K

Yamauchi, M

Kuriyama, T

机构：

[1] Natl Inst Radiol Sci, Space & Particle Radiat Sci Res Grp, Inage Ku, Chiba 2638555, Japan

[2] Chiba Univ, Sch Med, Dept Chest Med, Chuo Ku, Chiba 260, Japan

[3] Natl Inst Radiol Sci, Bioregulat Res Grp, Inage Ku, Chiba 263, Japan

[4] Natl Inst Radiol Sci, Genome Res Grp, Inage Ku, Chiba 263, Japan

来源：

CANCER LETTERS | 1998年 / 132卷 / 1-2期

关键词：

vascular endothelial growth factor; X-ray irradiation; Src tyrosine kinase; protein kinase C;

D O I：

10.1016/S0304-3835(98)00160-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor (VEGF) is a multipotent cytokine which plays an important role in various angiogenic conditions as well as in some tumor behaviors. Here we examined the induction of VEGF mRNA by X-ray irradiation in a lung squamous cell carcinoma cell line (RERF-LC-AI), Irradiating the cells with 15 Gy X-rays significantly increased the mRNA expression up to 2.5-fold of control at a post-irradiation time of 16-24 h. The induction of VEGF mRNA by X-ray irradiation was completely blocked by treating cells with either genistein (Src tyrosine kinase inhibitor) or H7 (protein kinase C inhibitor). This suggests that the mechanism of induction might be concerned with the pathway which triggers Src tyrosine kinase of the cell surface and the protein kinase C pathway. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：75 / 80

页数：6

共 32 条

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