Effective chromosome pairing requires chromatin remodeling at the onset of meiosis

被引：70

作者：

Colas, Isabelle ^{[1
]}

Shaw, Peter ^{[1
]}

Prieto, Pilar ^{[2
]}

Wanous, Michael ^{[3
]}

Spielmeyer, Wolfgang ^{[4
]}

Mago, Rohit ^{[4
]}

Moore, Graham ^{[1
]}

机构：

[1] John Innes Ctr, Norwich NR4 7UH, Norfolk, England

[2] Inst Agr Sostenible, Cordoba 14080, Spain

[3] Augustana Coll, Dept Biol, Sioux Falls, SD 57197 USA

[4] Commonwealth Sci & Ind Res Org, Canberra, ACT 2601, Australia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 16期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Ph1; wheat; heterochromatin; recombination; telomere;

D O I：

10.1073/pnas.0801521105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During meiosis, homologous chromosomes (homologues) recognize each other and then intimately associate. Studies exploiting species with large chromosomes reveal that chromatin is remodeled at the onset of meiosis before this intimate association. However, little is known about the effect the remodeling has on pairing. We show here in wheat that chromatin remodeling of homologues can only occur if they are identical or nearly identical. Moreover, a failure to undergo remodeling results in reduced pairing between the homologues. Thus, chromatin remodeling at the onset of meiosis enables the chromosomes to become competent to pair and recombine efficiently.

引用

页码：6075 / 6080

页数：6

共 29 条

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