Dengue vaccines: progress and challenges

被引：84

作者：

Coller, Beth-Ann G. ^{[1
]}

Clements, David E. ^{[1
]}

机构：

[1] Merck & Co Inc, Vaccines Res, West Point, PA 19486 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 03期

关键词：

HEMORRHAGIC-FEVER; CELLULAR-IMMUNITY; DISEASE SEVERITY; SOUTHEAST-ASIA; CLINICAL-TRIAL; PUBLIC-HEALTH; SEROTYPES; VIRUS; ANTIBODIES; NAIVE;

D O I：

10.1016/j.coi.2011.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With several dengue vaccine candidates progressing through clinical trials, several options for controlling this disease appear feasible. This would represent a major achievement and reflect decades of research and development activities. The challenges associated with the limited understanding of protective responses and those factors which determine disease severity remain, but with prospective studies ongoing in various dengue endemic areas and the initiation of dengue vaccine efficacy trials, immune responses are being evaluated in the context of protection and severe disease and these studies are highly likely to provide additional insights.

引用

页码：391 / 398

页数：8

共 66 条

[1] Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study [J].

Anderson, Katie B. ;

Chunsuttiwat, Supamit ;

Nisalak, Ananda ;

Mammen, Mammen P. ;

Libraty, Daniel H. ;

Rothman, Alan L. ;

Green, Sharone ;

Vaughn, David W. ;

Ennis, Francis A. ;

Endy, Timothy P. .

LANCET, 2007, 369 (9571) :1452-1459

[2] Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification [J].

Balsitis, Scott J. ;

Williams, Katherine L. ;

Lachica, Ruben ;

Flores, Diana ;

Kyle, Jennifer L. ;

Mehlhop, Erin ;

Johnson, Syd ;

Diamond, Michael S. ;

Beatty, P. Robert ;

Harris, Eva .

PLOS PATHOGENS, 2010, 6 (02)

[3] Evaluation of a prototype dengue-1 DNA vaccine in a Phase 1 clinical trial [J].

Beckett, Charmagne G. ;

Tjaden, Jeffrey ;

Burgess, Timothy ;

Danko, Janine R. ;

Tamminga, Cindy ;

Simmons, Monika ;

Wu, Shuenn-Jue ;

Sun, Peifang ;

Kochel, Tadeusz ;

Raviprakash, Kanakatte ;

Hayes, Curtis G. ;

Porter, Kevin R. .

VACCINE, 2011, 29 (05) :960-968

[4] The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity [J].

Beltramello, Martina ;

Williams, Katherine L. ;

Simmons, Cameron P. ;

Macagno, Annalisa ;

Simonelli, Luca ;

Quyen, Nguyen Than Ha ;

Sukupolvi-Petty, Soila ;

Navarro-Sanchez, Erika ;

Young, Paul R. ;

de Silva, Aravinda M. ;

Rey, Felix A. ;

Varani, Luca ;

Whitehead, Stephen S. ;

Diamond, Michael S. ;

Harris, Eva ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

CELL HOST & MICROBE, 2010, 8 (03) :271-283

[5] Development of a live attenuated dengue virus vaccine using reverse genetics [J].

Blaney, JE ;

Durbin, AP ;

Murphy, BR ;

Whitehead, SS .

VIRAL IMMUNOLOGY, 2006, 19 (01) :10-32

[6] Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys [J].

Blaney, JE ;

Matro, JM ;

Murphy, BR ;

Whitehead, SS .

JOURNAL OF VIROLOGY, 2005, 79 (09) :5516-5528

[7] Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1 [J].

Blaney, Joseph E., Jr. ;

Sathe, Neeraj S. ;

Hanson, Christopher T. ;

Firestone, Cai Yen ;

Murphy, Brian R. ;

Whitehead, Stephen S. .

VIROLOGY JOURNAL, 2007, 4 (1)

[8] Genotype-Specific Neutralization and Protection by Antibodies against Dengue Virus Type 3 [J].

Brien, James D. ;

Austin, S. Kyle ;

Sukupolvi-Petty, Soila ;

O'Brien, Katie M. ;

Johnson, Syd ;

Fremont, Daved H. ;

Diamond, Michael S. .

JOURNAL OF VIROLOGY, 2010, 84 (20) :10630-10643

[9] Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels [J].

Clark, DV ;

Mammen, MP ;

Nisalak, A ;

Puthimethee, V ;

Endy, TP .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 72 (06) :786-791

[10] Development of a recombinant tetravalent dengue virus vaccine: Innmunogenicity and efficacy studies in mice and monkeys [J].

Clements, David E. ;

Coller, Beth-Ann G. ;

Lieberman, Michael M. ;

Ogata, Steven ;

Wang, Gordon ;

Harada, Kent E. ;

Putnak, J. Robert ;

Ivy, John M. ;

McDonell, Michael ;

Bignami, Gary S. ;

Peters, Iain D. ;

Leung, Julia ;

Weeks-Levy, Carolyn ;

Nakano, Eileen T. ;

Humphreys, Tom .

VACCINE, 2010, 28 (15) :2705-2715

← 1 2 3 4 5 6 7 →