Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study

被引：77

作者：

Ding, C. ^{[1
]}

Parameswaran, V. ^{[2
]}

Cicuttini, Flavia M. ^{[3
]}

Burgess, J. ^{[2
]}

Zhai, G. ^{[1
,4
]}

Quinn, S. ^{[1
]}

Jones, G. ^{[1
]}

机构：

[1] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7000, Australia

[2] Royal Hobart Hosp, Diabet & Endocrine Serv, Hobart, Tas, Australia

[3] Monash Univ, Sch Med, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia

[4] Kings Coll London, Sch Med, Twin Res & Genet Epidemiol Unit, London WC2R 2LS, England

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2008年 / 67卷 / 09期

关键词：

D O I：

10.1136/ard.2007.082651

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To describe the associations between leptin, body composition, sex and knee cartilage volume/defects in older adults. Methods: A cross-sectional sample of 190 randomly selected subjects (mean 63 years, range 52-78, 48% female) were studied. Knee cartilage volume and defects were determined using T1-weighted fat saturation MRI. Serum leptin levels were measured by radioimmunoassay. Fat and lean mass were measured by dual energy x ray absorptiometry (DXA). Body mass index (BMI) was calculated. Results: In multivariable analysis, serum levels of leptin were negatively associated with total cartilage volume (beta: 2541 mm(3)/log transformed unit, 95% CI - 2861 to -2221) but not with prevalent knee cartilage defects. BMI was negatively associated with cartilage volume after adjustment for total lean mass and positively with prevalent knee cartilage defects. However, the association between BMI and cartilage volume disappeared after adjustment for leptin while the association between BMI and cartilage defects remained unchanged. Lastly, sex differences in total cartilage volume decreased substantially after adjustment for leptin (R-2 from 51% to 30%). Conclusions: This cross-sectional study suggests cartilage volume loss with obesity and female sex is related to leptin and, thus, is hormonally mediated in older adults. By contrast, obesity related knee focal cartilage defects may be more related to non-hormonal factors.

引用

页码：1256 / 1261

页数：6

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