Efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine based on breastfeeding frequency

被引：49

作者：

Goveia, Michelle G. ^{[1
]}

DiNubile, Mark J. ^{[1
]}

Dallas, Michael J. ^{[1
]}

Heaton, Penny M. ^{[1
]}

Kuter, Barbara J. ^{[1
]}

机构：

[1] Merck & Co Inc, West Point, PA 19486 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 07期

关键词：

rotavirus; gastroenteritis; pentavalent rotavirus vaccine; breastfeeding;

D O I：

10.1097/INF.0b013e318168d29e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of alive, oral, pentavalent rotavirus vaccine against G1-4 rotavirus gastroenteritis (RVGE) was retrospectively assessed based on breastfeeding frequency among 5098 infants in a placebo-controlled trial. The efficacy against any RVGE severity for infants never breastfed, sometimes breastfed, or exclusively breastfed was 68.3%, 82.2%, and 68.0%, respectively. The efficacy against severe RVGE was 100%, 95.4%, and 100%, respectively. Breastfeeding did not seem to adversely impact the efficacy of pentavalent rotavirus vaccine.

引用

页码：656 / 658

页数：3

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