A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)

被引：26

作者：

Ashour, Mohamed L. ^{[1
,2
]}

El-Readi, Mahmoud Z. ^{[1
,3
]}

Tahrani, Ahmed ^{[1
]}

Eid, Safaa Y. ^{[1
]}

Wink, Michael ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

[2] Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Cairo 11566, Egypt

[3] Al Azhar Univ, Dept Biochem, Fac Pharm, Assiut 71524, Egypt

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 02期

关键词：

Bupleurum marginatum; Chemical composition; Aryltetraline lactone; Cytotoxicity; ESSENTIAL OIL; AERIAL PARTS; BIOLOGICAL-ACTIVITY; LIGNANS; MODES; CELLS; ROOT;

D O I：

10.1016/j.phytol.2012.03.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3] dioxol-5-yl)-6,7,8-trimethoxy-3a, 4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques. The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay. The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 mu M after 24 h treatment for HepG2 and HeLa cells, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：387 / 392

页数：6

共 35 条

[1]

Ahmad V. U., 2007, SPECTROSCOPIC DATA S

[2]

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action [J].