Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma

被引：35

作者：

Yu, Bo ^{[1
]}

Wei, Jianhua ^{[1
]}

Qian, Xinhong ^{[2
]}

Lei, Delin ^{[1
]}

Ma, Qin ^{[1
]}

Liu, Yanpu ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Xijing Hosp, Xian 710032, Shannxi, Peoples R China

[2] Fourth Mil Med Univ, Sch Stomatol, Dept Pediat, Xijing Hosp, Xian 710032, Shannxi, Peoples R China

来源：

ONCOLOGY REPORTS | 2012年 / 27卷 / 02期

关键词：

Notch1; matrix metalloproteinase; invasion; lingual squamous cell carcinoma; ELECTIVE NECK DISSECTION; ORAL TONGUE CARCINOMA; MATRIX METALLOPROTEINASE-2; EXPRESSION; METASTASIS; TUMORIGENESIS; MARKER; TARGET; HEAD;

D O I：

10.3892/or.2011.1492

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Some studies show the Notch signaling pathway may participate in carcinoma invasion and metastasis. However, the mechanisms by which Notch1 mediates cell invasion and migration, especially in lingual squamous cell carcinoma, are not yet known. In the current study, we demonstrated for the first time the anti-invasion and anti-metastasis effect of down-regulation of Notch1 in lingual squamous cell carcinoma. Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis, which could be useful for devising novel preventive and therapeutic strategies for lingual squamous cell carcinoma.

引用

收藏

页码：547 / 552

页数：6

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