Chromosome condensation: Packaging the genome

被引：14

作者：

Uhlmann, F ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Chromosome Segregat Lab, London WC2A 3PX, England

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-9822(01)00214-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The packaging of centimetre long DNA molecules into compact metaphase chromosomes is essential for genome segregation in anaphase, The chromosomal condensin complex plays a crucial part in this packaging, and important new insight into condensin action in vitro and in vivo has recently been gained.

引用

页码：R384 / R387

页数：4

共 24 条

[1] Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with topoisomerase II [J].

Bhat, MA ;

Philp, AV ;

Glover, DM ;

Bellen, HJ .

CELL, 1996, 87 (06) :1103-1114

[2] Core histone N-termini play an essential role in mitotic chromosome condensation [J].

de la Barre, AE ;

Gerson, V ;

Gout, S ;

Creaven, M ;

Allis, CD ;

Dimitrov, S .

EMBO JOURNAL, 2000, 19 (03) :379-391

[3] TOPOISOMERASE-II IS A STRUCTURAL COMPONENT OF MITOTIC CHROMOSOME SCAFFOLDS [J].

EARNSHAW, WC ;

HALLIGAN, B ;

COOKE, CA ;

HECK, MMS ;

LIU, LF .

JOURNAL OF CELL BIOLOGY, 1985, 100 (05) :1706-1715

[4] The condensin complex governs chromosome condensation and mitotic transmission of rDNA [J].

Freeman, L ;

Aragon-Alcaide, L ;

Strunnikov, A .

JOURNAL OF CELL BIOLOGY, 2000, 149 (04) :811-824

[5] Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis [J].

Giet, R ;

Glover, DM .

JOURNAL OF CELL BIOLOGY, 2001, 152 (04) :669-681

[6] A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S-cerevisiae [J].

Guacci, V ;

Koshland, D ;

Strunnikov, A .

CELL, 1997, 91 (01) :47-57

[7] Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae [J].

Hartman, T ;

Stead, K ;

Koshland, D ;

Guacci, V .

JOURNAL OF CELL BIOLOGY, 2000, 151 (03) :613-626

[8] Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein [J].

Hirano, T ;

Kobayashi, R ;

Hirano, M .

CELL, 1997, 89 (04) :511-521

[9] A HETERODIMERIC COILED-COIL PROTEIN REQUIRED FOR MITOTIC CHROMOSOME CONDENSATION IN-VITRO [J].

HIRANO, T ;

MITCHISON, TJ .

CELL, 1994, 79 (03) :449-458

[10] Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily [J].

Hopfner, KP ;

Karcher, A ;

Shin, DS ;

Craig, L ;

Arthur, LM ;

Carney, JP ;

Tainer, JA .

CELL, 2000, 101 (07) :789-800

← 1 2 3 →