Is FOXP3 a bona fide marker for human regulatory T cells?

被引:154
作者
Roncarolo, Maria-Grazia [1 ,2 ]
Gregori, Silvia [1 ]
机构
[1] San Raffaele Telethon Inst Gene Therapy HSR TIGET, I-20132 Milan, Italy
[2] Universit Vita Salute San Raffaele, Milan, Italy
关键词
Adaptive IL-10-producing Tr1 cells; FOXP3; Naturally occurring regulatory T cells;
D O I
10.1002/eji.200838168
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
FOXP3 is a specific marker for naturally occurring regulatory T cells (nTreg). FOXP3 expression is correlated with development and function of nTreg. Recent evidence suggests that, upon activation, human effector T (Teff) cells and type 1 regulatory T (Tr1) cells can express FOXP3, albeit transiently. While the role of transient FOXP3 expression in Teff cells is poorly understood, it is becoming clear that it does not correlate with suppressor function. Furthermore, FOXP3-independent mechanisms, mediated by IL-10, contribute to the induction and suppressor functions of Tr1 cells.
引用
收藏
页码:925 / 927
页数:3
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