Pathogenesis of influenza A (H5N1) virus infection in a primate model

被引：202

作者：

Rimmelzwaan, GF

Kuiken, T

van Amerongen, G

Bestebroer, TM

Fouchier, RAM

Osterhaus, ADME

机构：

[1] Erasmus Univ, Inst Virol, Natl Influenza Ctr, Ctr Med, NL-3000 DR Rotterdam, Netherlands

[2] Natl Inst Publ Hlth & Environm, Cent Anim Lab, NL-3720 BA Bilthoven, Netherlands

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 14期

关键词：

D O I：

10.1128/JVI.75.14.6687-6691.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

引用

页码：6687 / 6691

页数：5

共 27 条

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