Solution phase synthesis of (1->5)-amide linked sugar amino acid dimers derived from sialic acids

被引:41
作者
Gervay, J
Flaherty, TM
Nguyen, C
机构
[1] Department of Chemistry, University of Arizona, Tucson
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(97)00138-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Carboxy-protected amino derivatives and amino-protected carboxy derivatives of three different C-2 analogs as well as a 2,3-dehydro NeuAc were prepared. These monomers were coupled in solution using BOP activation of the carboxy terminus to form (1-->5)-amide linked dimers of sialyl amino acid derivatives. (C) 1997 Elsevier Science Ltd.
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页码:1493 / 1496
页数:4
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