Neuroanatomical and neurochemical bases of theory of mind

被引:432
作者
Abu-Akel, Ahmad [1 ]
Shamay-Tsoory, Simone [2 ]
机构
[1] Independent, Los Angeles, CA 90012 USA
[2] Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel
关键词
Cognitive theory of mind; Affective theory of mind; Social cognition; Dopamine; Serotonin; Striatum; Ventral and dorsal attention systems; Self; Other; Autism; Schizophrenia; Parkinson's disease; CATECHOL-O-METHYLTRANSFERASE; TEMPORO-PARIETAL JUNCTION; MEDIAL PREFRONTAL CORTEX; SOCIAL COGNITION; PARKINSONS-DISEASE; FRONTAL-LOBE; TEMPOROPARIETAL JUNCTION; CINGULATE CORTEX; FRONTOTEMPORAL DEMENTIA; SCHIZOPHRENIC-PATIENTS;
D O I
10.1016/j.neuropsychologia.2011.07.012
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This paper presents a novel neurobiological model of theory of mind (ToM) that incorporates both neuroanatomical and neurochemical levels of specificity. Within this model, cortical and subcortical regions are functionally organized into networks that subserve the ability to represent cognitive and affective mental states to both self and other. The model maintains that (1) cognitive and affective aspects of ToM are subserved by dissociable, yet interacting, prefrontal networks. The cognitive ToM network primarily engages the dorsomedial prefrontal cortex, the dorsal anterior cingulate cortex and the dorsal striatum; and the affective ToM network primarily engages the ventromedial and orbitofrontal cortices, the ventral anterior cingulate cortex, the amygdala and the ventral striatum; (2) self and other mental-state representation is processed by distinct brain regions within the mentalizing network, and that the ability to distinguish between self and other mental states is modulated by a functionally interactive dorsal and ventral attention/selection systems at the temporoparietal junction and the anterior cingulate cortex; and (3) ToM functioning is dependent on the integrity of the dopaminergic and serotonergic systems which are primarily engaged in the maintenance and application processes of represented mental states. In addition to discussing the mechanisms involved in mentalizing in terms of its component processes, we discuss the model's implications to pathologies that variably impact one's ability to represent, attribute and apply mental states. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2971 / 2984
页数:14
相关论文
共 192 条
[1]   A neurobiological mapping of theory of mind [J].
Abu-Akel, A .
BRAIN RESEARCH REVIEWS, 2003, 43 (01) :29-40
[2]   The neurochemical hypothesis of 'theory of mind' [J].
Abu-Akel, A .
MEDICAL HYPOTHESES, 2003, 60 (03) :382-386
[3]   Untitled [J].
Abu-Akel, A ;
Bailey, AL .
PSYCHOLOGICAL MEDICINE, 2000, 30 (03) :735-738
[4]   Theory of mind in autism, schizophrenia, and in-between [J].
Abu-Akel, Ahmad .
BEHAVIORAL AND BRAIN SCIENCES, 2008, 31 (03) :261-+
[5]   Temporo-parietal Junction Activity in Theory-of-Mind Tasks: Falseness, Beliefs, or Attention [J].
Aichhorn, Markus ;
Perner, Josef ;
Weiss, Benjamin ;
Kronbichler, Martin ;
Staffen, Wolfgang ;
Ladurner, Gunther .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2009, 21 (06) :1179-1192
[6]  
Akil M, 2003, J NEUROSCI, V23, P2008
[7]   Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[8]   Theory of mind and schizophrenia: A positron emission tomography study of medication-free patients [J].
Andreasen, Nancy C. ;
Calage, Chadi A. ;
O'Leary, Daniel S. .
SCHIZOPHRENIA BULLETIN, 2008, 34 (04) :708-719
[9]  
[Anonymous], THEORY MIND SOTOS SY
[10]  
[Anonymous], THESIS U UTRECHT NET