Insights into autoimmunity gained from structural analysis of MHC-peptide complexes

被引：38

作者：

Wucherpfennig, KW ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(01)00274-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The structural and functional properties of HLA-DQ and -DR molecules that confer susceptibility to several common autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis and multiple sclerosis, have been defined. The relevant polymorphisms directly affect interaction with peptides, which provides strong support for the hypothesis that these diseases are peptide-antigen driven. Several studies indicate that structural modifications of peptides can affect MHC class II binding and/or TCR recognition and should be considered in the analysis of T cell responses in autoimmune diseases.

引用

页码：650 / 656

页数：7

共 56 条

[1] THE 1ST EXTERNAL DOMAIN OF THE NONOBESE DIABETIC MOUSE CLASS-II I-A BETA-CHAIN IS UNIQUE [J].

ACHAORBEA, H ;

MCDEVITT, HO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2435-2439

[2] A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin [J].

Alleva, DG ;

Crowe, PD ;

Jin, LP ;

Kwok, WW ;

Ling, N ;

Gottschalk, M ;

Conlon, PJ ;

Gottlieb, PA ;

Putnam, AL ;

Gaur, A .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (02) :173-180

[3] High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire [J].

Anderson, AC ;

Nicholson, LB ;

Legge, KL ;

Turchin, V ;

Zaghouani, H ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :761-770

[4] In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope [J].

Anderson, RP ;

Degano, P ;

Godkin, AJ ;

Jewell, DP ;

Hill, AVS .

NATURE MEDICINE, 2000, 6 (03) :337-342

[5] The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase [J].

Arentz-Hansen, H ;

Körner, R ;

Molberg, O ;

Quarsten, H ;

Vader, W ;

Kooy, YMC ;

Lundin, KEA ;

Koning, F ;

Roepstorff, P ;

Sollid, LM ;

McAdam, SN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :603-612

[6] One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies [J].

Bao, F ;

Yu, LP ;

Babu, S ;

Wang, TB ;

Hoffenberg, EJ ;

Rewers, M ;

Eisenbarth, GS .

JOURNAL OF AUTOIMMUNITY, 1999, 13 (01) :143-148

[7] Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire [J].

Cao, LG ;

Sun, DM ;

Whitaker, JN .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 88 (1-2) :21-29

[8] Identification of immunogenic epitopes of GAD 65 presented by A(g7) in non-obese diabetic mice [J].

Chao, CC ;

McDevitt, HO .

IMMUNOGENETICS, 1997, 46 (01) :29-34

[9] A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes [J].

Corper, AL ;

Stratmann, T ;

Apostolopoulos, V ;

Scott, CA ;

Garcia, KC ;

Kang, AS ;

Wilson, IA ;

Teyton, L .

SCIENCE, 2000, 288 (5465) :505-511

[10] X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II [J].

Dessen, A ;

Lawrence, CM ;

Cupo, S ;

Zaller, DM ;

Wiley, DC .

IMMUNITY, 1997, 7 (04) :473-481

← 1 2 3 4 5 6 →