Bridging gaps in phospholipid transport

被引:110
作者
Voelker, DR [1 ]
机构
[1] Natl Jewish Med & Res Ctr, Dept Med, Cell Biol Program, Denver, CO 80206 USA
关键词
D O I
10.1016/j.tibs.2005.05.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phospholipid transport between membranes is a fundamental aspect of organelle biogenesis in eukaryotes; however, little is know about this process. A significant body of data demonstrates that newly synthesized phospholipids can move between membranes by routes that are independent of the vesicular traffic that carries membrane proteins. Evidence continues to accumulate in support of a system for phospholipid transport that occurs at zones of apposition and contact between donor membranes - the source of specific phospholipids - and acceptor membranes that are unable to synthesize the necessary lipids. Recent findings identify some of the lipids and proteins that must be present on membranes for inter-organelle phospholipid transport to occur between the endoplasmic reticulum and mitochondria or Golgi. These data suggest that protein and lipid assemblies on donors and acceptors promote membrane docking and facilitate lipid movement.
引用
收藏
页码:396 / 404
页数:9
相关论文
共 49 条
[1]  
ACHLEITNER G, 1995, J BIOL CHEM, V270, P29836
[2]   Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact [J].
Achleitner, G ;
Gaigg, B ;
Krasser, A ;
Kainersdorfer, E ;
Kohlwein, SD ;
Perktold, A ;
Zellnig, G ;
Daum, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (02) :545-553
[3]   Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade [J].
Audhya, A ;
Emr, SD .
DEVELOPMENTAL CELL, 2002, 2 (05) :593-605
[4]   AN ESSENTIAL ROLE FOR A PHOSPHOLIPID TRANSFER PROTEIN IN YEAST GOLGI FUNCTION [J].
BANKAITIS, VA ;
AITKEN, JR ;
CLEVES, AE ;
DOWHAN, W .
NATURE, 1990, 347 (6293) :561-562
[5]   COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast [J].
Bednarek, SY ;
Ravazzola, M ;
Hosobuchi, M ;
Amherdt, M ;
Perrelet, A ;
Schekman, R ;
Orci, L .
CELL, 1995, 83 (07) :1183-1196
[6]   Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes [J].
Carman, GM ;
Henry, SA .
PROGRESS IN LIPID RESEARCH, 1999, 38 (5-6) :361-399
[7]   Membrane-protein interactions in cell signaling and membrane trafficking [J].
Cho, WH ;
Stahelin, RV .
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2005, 34 :119-151
[8]   Continuous equilibration of phosphatidylcholine and its precursors between endoplasmic reticulum and mitochondria in yeast [J].
de Kroon, AIPM ;
Koorengevel, MC ;
Vromans, TAM ;
de Kruijff, B .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (05) :2142-2150
[9]   SCF and cullin/RING H2-based ubiquitin ligases [J].
Deshaies, RJ .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :435-467
[10]   Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine [J].
Emoto, K ;
Kuge, O ;
Nishijima, M ;
Umeda, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12400-12405