First total synthesis of an exceptionally potent antitumor saponin, OSW-1

被引：139

作者：

Deng, SJ ^{[1
]}

Yu, B ^{[1
]}

Lou, Y ^{[1
]}

Hui, YZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 01期

关键词：

D O I：

10.1021/jo981685c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.

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页码：202 / 208

页数：7

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