Ca2+ permeability of nicotinic acetylcholine receptors

被引：264

作者：

Fucile, S

机构：

[1] Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, I-00185 Rome, Italy

[2] Dipartimento Sci Internist, I-00163 Rome, Italy

来源：

CELL CALCIUM | 2004年 / 35卷 / 01期

关键词：

Ca2+ permeability; nicotinic acetylcholine receptors; fractional Ca2+ current; P-Ca/P-Na ratio;

D O I：

10.1016/j.ceca.2003.08.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca2+. Ca2+ entry through nAChR channels has been shown to modulate several Ca2+-dependent cellular processes, such as neurotransmitter release, synaptic plasticity, and cell motility. The value of Ca2+ permeability associated to a particular nAChR subtype thus represents an important indication for its physiological role. This review summarizes the quantitative data on Ca2+ permeability obtained from several nAChR subtypes in native and heterologous systems. Different experimental approaches are compared, and the structural determinants of Ca2+ permeability are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

共 98 条

[1] CALCIUM PERMEABILITY AND MODULATION OF NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNELS IN RAT PARASYMPATHETIC NEURONS [J].