Nano-biotechnology: carbon nanofibres as improved neural and orthopaedic implants

被引:259
作者
Webster, TJ [1 ]
Waid, MC [1 ]
McKenzie, JL [1 ]
Price, RL [1 ]
Ejiofor, JU [1 ]
机构
[1] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA
关键词
D O I
10.1088/0957-4484/15/1/009
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
For the continuous monitoring, diagnosis, and treatment of neural tissue, implantable probes are required. However, sometimes such neural probes (usually composed of silicon) become encapsulated with non-conductive, undesirable glial scar tissue. Similarly for orthopaedic implants, biomaterials (usually titanium and/or titanium alloys) often become encapsulated with undesirable soft fibrous, not hard bony, tissue. Although possessing intriguing electrical and mechanical properties for neural and orthopaedic applications, carbon nanofibres/nanotubes have not been widely considered for these applications to date. The present work developed a carbon nanofibre reinforced polycarbonate urethane (PU) composite in an attempt to determine the possibility of using carbon nanofibres (CNs) as either neural or orthopaedic prosthetic devices. Electrical and mechanical characterization studies determined that such composites have properties suitable for neural and orthopaedic applications. More importantly, cell adhesion experiments revealed for the first time the promise these materials have to increase neural (nerve cell) and osteoblast (bone-forming cell) functions. In contrast, functions of cells that contribute to glial scar-tissue formation for neural prostheses (astrocytes) and fibrous-tissue encapsulation events for bone implants (fibroblasts) decreased on PU composites containing increasing amounts of CNs. In this manner, this study provided the first evidence of the future that CN formulations may have towards interacting with neural and bone cells which is important for the design of successful neural probes and orthopaedic implants, respectively.
引用
收藏
页码:48 / 54
页数:7
相关论文
共 35 条
[1]   CARBON FIBER-REINFORCED CARBON AS A POTENTIAL IMPLANT MATERIAL [J].
ADAMS, D ;
WILLIAMS, DF ;
HILL, J .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1978, 12 (01) :35-42
[2]  
AYAD L, 1994, EXTRACELLULAR MATRIX
[3]   FTIR study of a nanostructured aluminum nitride powder surface: Determination of the acidic/basic sites by CO, CO2 and acetic acid adsorptions [J].
Baraton, MI ;
Chen, X ;
Gonsalves, KE .
NANOSTRUCTURED MATERIALS, 1997, 8 (04) :435-445
[4]   NANOCRYSTALLINE INTERMETALLIC COMPOUNDS - AN APPROACH TO DUCTILITY [J].
BOHN, R ;
HAUBOLD, T ;
BIRRINGER, R ;
GLEITER, H .
SCRIPTA METALLURGICA ET MATERIALIA, 1991, 25 (04) :811-816
[5]  
BRUNSKI JB, 1991, BONE-BIOMATERIAL INTERFACE, P391
[6]   STRUCTURAL SUPERPLASTICITY IN SINGLE-PHASE CRYSTALLINE CERAMICS [J].
CARRY, C ;
MOCELLIN, A .
CERAMICS INTERNATIONAL, 1987, 13 (02) :89-98
[7]   Effect of nitrogen addition on the microstructure and mechanical properties of diamond films grown using high-methane concentrations [J].
Catledge, SA ;
Vohra, YK .
JOURNAL OF APPLIED PHYSICS, 1999, 86 (01) :698-700
[8]  
CIFTCIOGLU MH, 1990, MATER RES SOC SYMP P, V196, P77, DOI 10.1557/PROC-196-77
[9]  
Cui Z., 1992, Nanostructured Materials, V1, P419, DOI 10.1016/0965-9773(92)90092-C
[10]   Bending properties of carbon nanotubes encapsulating solid nanowires [J].
Danailov, D ;
Keblinski, P ;
Nayak, S ;
Ajayan, PM .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2002, 2 (05) :503-507