Orexin A-like immunoreactivity in the rat brain

被引：151

作者：

Chen, CT

Dun, SL

Kwok, EH

Dun, NJ

Chang, JK

机构：

[1] E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA

[2] Phoenix Pharmaceut, Mt View, CA 94043 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 260卷 / 03期

关键词：

arcuate nucleus; lateral hypothalamus; median eminence; obesity;

D O I：

10.1016/S0304-3940(98)00977-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Distribution of orexin-A-like immunoreactivity (ORX-LI) in rat brains was investigated with the use of a rabbit polyclonal antibody against the full length peptide orexin A. Virtually all the ORX-LI cell bodies were observed in the lateral hypothalamus at the level of median eminence. The large majority of ORX-LI neurons appeared spherical or fusiform, 20-30 mu m in diameter and issued two to five cell processes with few secondary branchings. Numerous ORX-LI fibers were observed in subregions of the hypothalamus. ORX-LI cell processes were sparsely distributed in the cortex, hippocampus and thalamus. Many varicose ORX-LI cell processes were situated close to the 3rd and lateral ventricles, some of which appeared to be protruding into the lumen. As a corollary, orexin A may be released into the ventricles and interact with neurons in distant targets, in addition to influencing the activity of neurons with which ORX-LI axons make synaptic contacts. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：161 / 164

页数：4

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