Reaction crystallization of pharmaceutical molecular complexes

被引：248

作者：

Rodriguez-Hornedo, Nair ^{[1
]}

Nehru, Sarah J. ^{[1
]}

Seefeldt, Kurt F. ^{[1
]}

Pagan-Torres, Yomaira ^{[1
]}

Falkiewicz, Christopher J. ^{[1
]}

机构：

[1] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

来源：

MOLECULAR PHARMACEUTICS | 2006年 / 3卷 / 03期

关键词：

solution-mediated transformation; cocrystal; cocrystallization; solubility product; Raman spectroscopy;

D O I：

10.1021/mp050099m

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A mechanism for cocrystal synthesis is reported whereby nucleation and growth of cocrystals are directed by the effect of the cocrystal components on reducing the solubility of the molecular complex to be crystallized. The carbamazepine:nicotinamide cocrystal (CBZ:NCT) was chosen as a model system to study the reaction cocrystallization pathways and kinetics in aqueous and organic solvents. Fiber optic Raman spectroscopy and Raman microscopy were used for in situ monitoring of the cocrystallization in macroscopic and microscopic scales in solutions, suspensions, slurries, and wet solid phases of cocrystal components. This study demonstrates the advantages of reaction cocrystallization methods to develop rational approaches for high-throughput screening of cocrystals that can be transferable to control batch and continuous cocrystallization processes.

引用

页码：362 / 367

页数：6

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