In vitro antimicrobial efficacy of silver iontophoretic catheter

被引：30

作者：

Raad, I ^{[1
]}

Hachem, R ^{[1
]}

Zermeno, A ^{[1
]}

Dumo, M ^{[1
]}

Bodey, GP ^{[1
]}

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT BIOMED CLIN ENGN, HOUSTON, TX 77030 USA

来源：

BIOMATERIALS | 1996年 / 17卷 / 11期

关键词：

catheters; silver iontophoretic; broad spectrum activity; electrochemical barrier;

D O I：

10.1016/0142-9612(96)85905-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A silver iontophoretic catheter was designed consisting of two silver wires connected to an electric power source and disposed in a parallel and helical manner around the proximal subcutaneous segment of a silicone catheter. In an in vitro tunnelled bridge model the silver iontophoretic catheter prevented the migration of Staphylococcus epidermidis from the highly contaminated hub to the sterile tip over a 40-d period. The silver impregnated cuff and electrically charged wires made of aluminium or iron delayed migration for only 72 h. A modified Kirby-Bauer technique, used to test the inhibitory activity of antimicrobial catheters, showed that the silver iontophoretic catheter has a broad spectrum inhibitory activity against Gram-positive bacteria, Gram-negative bacteria and Candida albicans. The silver iontophoretic catheter provides a long-term electrochemical barrier against the migration of organisms from the external contaminated environment into the sterile intravascular compartment. (C) 1996 Elsevier Science Limited

引用

页码：1055 / 1059

页数：5

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