Face off - the interplay between activating and inhibitory immune receptors

被引:120
作者
Lanier, LL
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0952-7915(00)00222-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors. Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions.
引用
收藏
页码:326 / 331
页数:6
相关论文
共 86 条
  • [1] Bachmann MF, 1999, J IMMUNOL, V163, P1128
  • [2] DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    Bakker, ABH
    Hoek, RM
    Cerwenka, A
    Blom, B
    Lucian, L
    McNeil, T
    Murray, R
    Phillips, JH
    Sedgwick, JD
    Lanier, LL
    [J]. IMMUNITY, 2000, 13 (03) : 345 - 353
  • [3] Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily
    Banham, AH
    Colonna, M
    Cella, M
    Micklem, KJ
    Pulford, K
    Willis, AC
    Mason, DY
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 65 (06) : 841 - 845
  • [4] The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
    Baroja, ML
    Luxenberg, D
    Chau, T
    Ling, V
    Strathdee, CA
    Carreno, BM
    Madrenas, J
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (01) : 49 - 55
  • [5] The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
    Bléry, M
    Kubagawa, H
    Chen, CC
    Vély, F
    Cooper, MD
    Vivier, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2446 - 2451
  • [6] Borges L, 1997, J IMMUNOL, V159, P5192
  • [7] Brooke GP, 1998, EUR J IMMUNOL, V28, P1, DOI 10.1002/(SICI)1521-4141(199801)28:01&lt
  • [8] 1::AID-IMMU1&gt
  • [9] 3.0.CO
  • [10] 2-V