Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4

被引：20

作者：

Phillips, ED ^{[1
]}

Chang, HF ^{[1
]}

Holmquist, CR ^{[1
]}

McCauley, JP ^{[1
]}

机构：

[1] AstraZeneca R&D Wilmington, Dept Chem, Wilmington, DE 19850 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00667-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A(4). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3223 / 3226

页数：4

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