Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain

被引：64

作者：

Johnson, RA

Mitchell, GS

机构：

[1] Dept. of Comparative Biosciences, University of Wisconsin, Madison, WI 53706

来源：

BRAIN RESEARCH | 2003年 / 983卷 / 1-2期

关键词：

neurotrophin; physical activity; genetics; exercise; plasticity;

D O I：

10.1016/S0006-8993(03)03039-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested the hypothesis that exercise-induced changes in hippocampal brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) differ among rat strains exhibiting a range of voluntary wheel running activity. Four strains (Sprague-Dawley, Brown Norway, Dark Agouti and PVG) were given access to running wheels (I or 7 nights). Over 7 nights, the average distance run per night was higher in PVG versus other strains, and higher in Brown Norway versus Sprague-Dawley rats. Hippocampal BDNF concentrations in sedentary rats were higher in PVG versus Sprague-Dawley rats. When data from all strains were combined, BDNF levels increased with 7 nights of wheel running and were positively correlated to the previous night distance run. Sedentary hippocampal NT-3 levels were not different between rat strains, but decreased with 7 nights of wheel access; NT-3 was negatively correlated with previous night distance run. There were no differences between strains in the correlation between distance run and BDNF or NT-3 levels. Although exercise decreases hippocampal NT-3, strain does not alter NT-3 levels. In contrast, BDNF levels increase with exercise and basal levels differ between strains, possibly due to strain differences in spontaneous activity. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：108 / 114

页数：7

共 54 条

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