Increased levels of D-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility

被引：78

作者：

Errico, Francesco ^{[1
]}

Nistico, Robert ^{[2
,3
]}

Palma, Giuseppe ^{[1
]}

Federici, Mauro ^{[2
]}

Affuso, Andrea ^{[4
]}

Brilli, Elisa ^{[5
]}

Topo, Enza ^{[6
]}

Centonze, Diego ^{[2
,7
]}

Bernardi, Giorgio ^{[2
,7
]}

Bozzi, Yuri ^{[5
]}

D'Aniello, Antimo ^{[6
]}

Di Lauro, Roberto ^{[4
]}

Mercuri, Nicola B. ^{[2
,7
]}

Usiello, Alessandro ^{[1
,8
]}

机构：

[1] CEINGE Biotecnol Avanzate, Lab Behav Neurosci, I-80145 Naples, Italy

[2] CERC Fdn Santa Lucia, Rome, Italy

[3] Univ Calabria, Dept Pharmacobiol, I-87036 Cosenza, Italy

[4] Biogem SCArL, IRGS, Avellino, Italy

[5] CNR, Ist Neurosci, I-56100 Pisa, Italy

[6] Staz Zool A Dohrn, Dept Neurobiol, Naples, Italy

[7] Univ Tor Vergata, Neurol Clin, Rome, Italy

[8] Univ Molise, Dept Hlth Sci, Campobasso, Italy

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2008年 / 37卷 / 02期

关键词：

D-aspartate; hippocamus; NMDA receptors; long-term potentiation; Morris water maze; cognitive flexibility;

D O I：

10.1016/j.mcn.2007.09.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we demonstrate a direct role for D-aspartate in regulating hippocampal synaptic plasticity. These evidences were obtained using two different experimental strategies which enabled a non-physiological increase of endogenous D-aspartate levels in the mouse hippocampus: a genetic approach based on the targeted deletion Of D-aspartate oxidase gene and another based on the oral administration of D-aspartate. Overall, our results indicate that increased D-aspartate content does not affect basal properties of synaptic transmission but enhances long-term potentiation in hippocampal slices from both genetic and pharmacological animal models. Besides electrophysiological data, behavioral analysis suggests that altered levels Of D-aspartate in the hippocampus do not perturb basal spatial learning and memory abilities, but may selectively interfere with the dynamic NMDAR-dependent processes underlying cognitive flexibility. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：236 / 246

页数：11

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