Time course of blood oxygenation level-dependent signal response after theta burst transcranial magnetic stimulation of the frontal eye field

被引：64

作者：

Hubl, D. ^{[1
,2
,4
]}

Nyffeler, T. ^{[1
,4
]}

Wurtz, P. ^{[1
,4
]}

Chaves, S. ^{[1
,4
]}

Pflugshaupt, T. ^{[1
,4
]}

Luethi, M. ^{[1
,4
]}

Von Wartburg, R. ^{[1
,4
]}

Wiest, R. ^{[3
]}

Dierks, T.

Strik, W. K. ^{[2
]}

Hess, C. W. ^{[1
,2
,4
]}

Mueri, R. M. ^{[1
,4
]}

机构：

[1] Univ Bern, Univ Hosp, Dept Neurol, Percept & Eye Movement Lab, CH-3010 Bern, Switzerland

[2] Univ Hosp Psychiat Bern, CH-3000 Bern, Switzerland

[3] Univ Bern, Inselspital, Inst Diagnost & Intervent Neuroradiol, CH-3010 Bern, Switzerland

[4] Univ Bern, Univ Hosp, Dept Clin Res, Percept & Eye Movement Lab, CH-3010 Bern, Switzerland

来源：

NEUROSCIENCE | 2008年 / 151卷 / 03期

关键词：

saccades; FEF; PEF; humans; fMRI; TMS;

D O I：

10.1016/j.neuroscience.2007.10.049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the current study was to examine the effect of theta burst repetitive transcranial magnetic stimulation (rTMS) on the blood oxygenation level-dependent (BOLD) activation during repeated functional magnetic resonance imaging (fMRI) measurements. Theta burst rTMS was applied over the right frontal eye field in seven healthy subjects. Subsequently, repeated fMRI measurements were performed during a saccade-fixation task (block design) 5, 20, 35, and 60 min after stimulation. We found that theta burst rTMS induced a strong and long-lasting decrease of the BOLD signal response of the stimulated frontal eye field at 20 and 35 min. Furthermore, less pronounced alterations of the BOLD signal response with different dynamics were found for remote oculomotor areas such as the left frontal eye field, the pre-supplementary eye field, the supplementary eye field, and both parietal eye fields. Recovery of the BOLD signal changes in the anterior remote areas started earlier than in the posterior remote areas. These results show that a) the major inhibitory impact of theta burst rTMS occurs directly in the stimulated area itself, and that b) a lower effect on remote, oculomotor areas can be induced. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：921 / 928

页数：8

共 49 条

[1]

Berlucchi G., 1990, HDB NEUROPSYCHOLOGY, V4, P9

[2] Functional MRI of the immediate impact of transcranial magnetic stimulation on cortical and subcortical motor circuits [J].