Measurement of allergenic potency using the local lymph node assay

被引：35

作者：

Basketter, DA ^{[1
]}

Gerberick, GF

Kimber, I

机构：

[1] Unilever Res, Colworth House, SEAC Toxicol Unit, Sharnbrook MK44 1LQ, Beds, England

[2] Div Human & Environm Safety, Cincinnati, OH USA

[3] Syngenta Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 06期

关键词：

D O I：

10.1016/S0165-6147(00)01704-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemicals that can act as contact allergens have been identified successfully using guinea-pig models. However, contact allergy is still common, probably because of, at least in part. failures of risk assessment. A new method, the local lymph node assay, replaces the guinea-pig as a tool for hazard identification and offers the real prospect of accurate prediction of allergen potency, the missing link in skin sensitization risk assessment.

引用

页码：264 / 265

页数：2

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