Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?

被引：119

作者：

Kateb, Babak ^{[1
,2
,3
,4
,5
]}

Chiu, Katherine ^{[6
]}

Black, Keith L. ^{[5
]}

Yamamoto, Vicky ^{[4
]}

Khalsa, Bhavraj ^{[6
]}

Ljubimova, Julia Y. ^{[5
]}

Ding, Hui ^{[5
]}

Patil, Rameshwar ^{[5
]}

Portilla-Arias, Jose Antonio ^{[5
]}

Modo, Mike ^{[8
]}

Moore, David F. ^{[1
,7
]}

Farahani, Keyvan ^{[13
]}

Okun, Michael S. ^{[1
,10
,11
]}

Prakash, Neal ^{[1
,12
]}

Neman, Josh ^{[9
]}

Ahdoot, Daniel ^{[2
]}

Grundfest, Warren ^{[1
,2
,9
]}

Nikzad, Shouleh ^{[1
,2
,4
,15
]}

Heiss, John D. ^{[1
,14
]}

机构：

[1] IBMISPS, 8159 Santa Monica Blvd,Suite 200, W Hollywood, CA 90046 USA

[2] Brain Mapping Fdn, W Hollywood, CA 90046 USA

[3] Univ So Calif, Viterbi Sch Engn, Los Angeles, CA 90089 USA

[4] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[5] Cedars Sinai Med Ctr, Maxine Dunitz Neurosurg Inst, Los Angeles, CA 90048 USA

[6] Univ Calif Irvine, Sch Med, Irvine, CA 92697 USA

[7] Walter Reed Army Med Ctr, DVBIC, Washington, DC 20307 USA

[8] Kings Coll London, London WC2R 2LS, England

[9] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[10] Univ Florida, Movement Disorders Ctr, Dept Neurol, Gainesville, FL 32610 USA

[11] Univ Florida, Movement Disorders Ctr, Dept Neurosurg, Gainesville, FL 32610 USA

[12] Univ Hawaii, John A Burns Sch Med, Manoa, HI 96813 USA

[13] NCI, Bethesda, MD 20892 USA

[14] NINDS, Bethesda, MD 20824 USA

[15] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA

来源：

NEUROIMAGE | 2011年 / 54卷

关键词：

Nanoplatforms; Nanotechnology; Image-guided therapy; Nanomedicine; Nanoneurosurgery; Nanostructures; Contrast agents; Nanoparticles; Nanotechnology policy; Nano-radiology; Nano-neuroscience; Nano-neurology; NEPHROGENIC SYSTEMIC FIBROSIS; IRON-OXIDE NANOPARTICLES; MAGNETIC-RESONANCE TRACKING; FUNCTIONALIZED CARBON NANOTUBES; MRI CONTRAST AGENTS; VX-2 RABBIT TUMORS; IN-VIVO; QUANTUM DOTS; STEM-CELLS; BIODEGRADABLE NANOPARTICLES;

D O I：

10.1016/j.neuroimage.2010.01.105

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1-100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds, nanotechnology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nano-immunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law-healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：S106 / S124

页数：19

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