Transcriptional regulation by changes in tonicity

被引：56

作者：

Handler, JS ^{[1
]}

Kwon, HM ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Div Nephrol, Baltimore, MD 21205 USA

来源：

KIDNEY INTERNATIONAL | 2001年 / 60卷 / 02期

关键词：

TonEBP; calcineurin; cyclosporine A; myoinositol; betaine; taurine; sorbitol;

D O I：

10.1046/j.1523-1755.2001.060002408.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contrast to high concentrations of electrolytes, the small organic solutes do not perturb the activity of enzymes and other macromolecules within the cell. When the renal medulla becomes hypertonic during antidiuresis, multiple signaling pathways are activated. Here. we: review the role of tonicity responsive enhancers (TonE) binding protein (TonEBP), a transcription factor activated in hypertonic cells. The activation of TonEBP by hypertonicity results from its translocation to the nucleus as well as an increase in TonEBP mRNA and protein. TonEBP may have a role beyond the response to tonicity since it is highly expressed in activated lymphocytes and in developing tissues.

引用

页码：408 / 411

页数：4

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