A new view of mRNA export: Separating the wheat from the chaff

被引：68

作者：

Reed, R ^{[1
]}

Magni, K ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 09期

关键词：

D O I：

10.1038/ncb0901-e201

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins - the hnRNP proteins - have a key role in exporting mRNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export factor ALY, which are recruited to the mRNA during pre-mRNA splicing. These studies, together with older work on hnRNP particles and assembly of the spliceosome, lead us to a new view of mRNA export. In our model, the non-hnRNP factors form a splicing-dependent mRNP complex that specifically targets mature mRNA for export, while hnRNP proteins retain introns in the nucleus. A machinery that is conserved between yeast and higher eukaryotes functions to export the mRNA.

引用

页码：E201 / E204

页数：4

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