A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats

被引：55

作者：

Browman, KE ^{[1
]}

Curzon, P ^{[1
]}

Pan, JB ^{[1
]}

Molesky, AL ^{[1
]}

Komater, VA ^{[1
]}

Decker, MW ^{[1
]}

Brioni, JD ^{[1
]}

Moreland, RB ^{[1
]}

Fox, GB ^{[1
]}

机构：

[1] Abbott Labs, Neurosci Res, Abbott Pk, IL 60064 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2005年 / 82卷 / 01期

关键词：

A-412997; CP226269; PD168077; social recognition; 5-trial inhibitory avoidance;

D O I：

10.1016/j.pbb.2005.08.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The recent development of a highly selective dopamine D-4 receptor agonist, A-412997 (2-(3',4',5',6'-tetrahydro-2'H-[2,4'] bipyridinyl-1'yl)-N-m-tolyl-acetamide), has provided a pharmacological too] with which to conduct systematic investigations into the putative role for dopamine D-4 receptors in the central nervous system. These present studies evaluated the potential cognitive enhancing properties of A-412997 in rat models of ADHD (5-trial repeated acquisition inhibitory avoidance in Spontaneous Hypertensive Rat pups) and short-term memory (Social Recognition), in comparison with the less selective dopamine D-4 receptor agonists PD168077 and CP226269. A-412997 showed significant dose-dependent efficacy in both models. PD168077 repeatedly improved acquisition in the 5-trial inhibitory avoidance model but failed to reach significance at any dose tested, although significantly improved social recognition was observed (albeit less potent than A-412997). CP226269 showed a significant enhancement in the 5-trial inhibitory avoidance model. These results support a role for the dopamine D4 receptor subtype in cognition. (c) 2005 Elsevier Inc. All rights reserved.

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页码：148 / 155

页数：8

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