Hippocampal GABAergic interneurons:: A physiological perspective

被引:44
作者
Buzsáki, G [1 ]
机构
[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
关键词
oscillation; plasticity; temporal code; hippocampus; interneurons; principal cells; theta; gamma;
D O I
10.1023/A:1012324231897
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oscillations within and across neuronal systems are believed to serve various complex functions, such as perception, cognition, movement initiation, plasticity and memory. GABAergic interneurons and their inhibitory synapses play a major role in these oscillatory patterns. Networks of inhibitory interneurons impose a coordinated oscillatory "context" for the "content" carried by networks of principal cells. This hypothesis implies that GABAergic neuronal "supernetworks" may cooperatively entrain large populations of pyramidal cells throughout the forebrain. Experiments on hippocampal interneurons are reviewed and possible solutions for some of these complex functions are illustrated.
引用
收藏
页码:899 / 905
页数:7
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