Effects of methamphetamine-induced neurotoxicity on the development of neural circuitry: a hypothesis

被引：59

作者：

Frost, DO

Cadet, JL

机构：

[1] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Neurosci Program, Baltimore, MD 21201 USA

[3] NIDA, Mol Neuropsychiat Sect, Baltimore, MD USA

来源：

BRAIN RESEARCH REVIEWS | 2000年 / 34卷 / 03期

关键词：

dopamine; serotonin; neuroplasticity; free radicals; apoptosis;

D O I：

10.1016/S0165-0173(00)00042-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exposure of the developing brain to methamphetamine has well-studied biochemical and behavioral consequences. We review: (1) the effects of methamphetamine on mature serotonergic and dopaminergic pathways; (2) the mechanisms of methamphetamine neurotoxicity and (3) the role of serotonergic and dopaminergic signaling in sculpting developing neural circuitry. Consideration of these data suggest the types of neural circuit alterations that may result from exposure of the developing brain to methamphetamine and that may underlie functional defects. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：103 / 118

页数：16

共 247 条

[1] Stage-specific effects of prenatal d-methamphetamine exposure on behavioral and eye development in rats [J].