Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients

被引：11

作者：

Andrés, MT

Viejo-Diaz, M

Pérez, F

Fierro, JF

机构：

[1] Univ Oviedo, Fac Med, Dept Funct Biol Microbiol, Oviedo 33006, Spain

[2] Univ Oviedo, Lab Oral Microbiol, Sch Stomatol, Oviedo 33006, Spain

[3] Hosp Cent Asturias, Dept Microbiol 1, Oviedo, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1613-1616.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginusa isolates from cystic fibrosis patients showed higher ATE values (<= 6-fold) than other clinical strains.

引用

收藏

页码：1613 / 1616

页数：4

相关论文

共 15 条

[1] The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains [J].

Alkawash, M ;

Head, M ;

Alshami, I ;

Soothill, JS .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (03) :385-387

[2]

[Anonymous], M07A6 NCCLS

[3] ROLES OF RIBOSOMAL-BINDING, MEMBRANE-POTENTIAL, AND ELECTRON-TRANSPORT IN BACTERIAL UPTAKE OF STREPTOMYCIN AND GENTAMICIN [J].

BRYAN, LE ;

KWAN, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (06) :835-845

[4] MICs of rifampicin and chloramphenicol for mucoid Pseudomonas aeruginosa strains are lower when human lactoferrin is present [J].

Fowler, CE ;

Soothill, JS ;

Oakes, L .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (06) :877-879

[5] TOBRAMYCIN UPTAKE IN ESCHERICHIA-COLI IS DRIVEN BY EITHER ELECTRICAL POTENTIAL OR ATP [J].

FRAIMOW, HS ;

GREENMAN, JB ;

LEVITON, IM ;

DOUGHERTY, TJ ;

MILLER, MH .

JOURNAL OF BACTERIOLOGY, 1991, 173 (09) :2800-2808

[6] INVOLVEMENT OF THE OUTER-MEMBRANE IN GENTAMICIN AND STREPTOMYCIN UPTAKE AND KILLING IN PSEUDOMONAS-AERUGINOSA [J].

HANCOCK, REW ;

RAFFLE, VJ ;

NICAS, TI .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1981, 19 (05) :777-785

[7]

HARBITZ O, 1984, EUR J RESPIR DIS, V65, P512

[8] Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function [J].

Hentzer, M ;

Teitzel, GM ;

Balzer, GJ ;

Heydorn, A ;

Molin, S ;

Givskov, M ;

Parsek, MR .

JOURNAL OF BACTERIOLOGY, 2001, 183 (18) :5395-5401

[9] New antimicrobials in the management of cystic fibrosis [J].

Hoiby, N .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (02) :235-238

[10] Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates [J].

Kuipers, ME ;

de Vries, HG ;

Eikelboom, MC ;

Meijer, DKF ;

Swart, PJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2635-2641