The viral potassium channel Kcv: structural and functional features

被引：45

作者：

Gazzarrini, S

Severino, M

Lombardi, M

Morandi, M

DiFrancesco, D

Van Etten, JL

Thiel, G

Moroni, A

机构：

[1] Univ Milan, Dept Biol, CNR, IBF,Unita Milano, I-20133 Milan, Italy

[2] Univ Milan, Dept Gen Physiol & Biochem, I-20133 Milan, Italy

[3] Unita Milano Univ, INFM, I-20133 Milan, Italy

[4] Univ Nebraska, Dept Plant Pathol, Lincoln, NE 68583 USA

[5] TH Darmstadt, Inst Bot, D-64287 Darmstadt, Germany

来源：

FEBS LETTERS | 2003年 / 552卷 / 01期

关键词：

K+ channel; Kcv; PBCV-1; chlorella virus;

D O I：

10.1016/S0014-5793(03)00777-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：12 / 16

页数：5

共 21 条

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