Antinociceptive effect of extract of Emilia sonchifolia in mice

被引：51

作者：

Couto, Veronica M. ^{[1
]}

Vilela, Fabiana C. ^{[1
]}

Dias, Danielle F. ^{[1
]}

dos Santos, Marcelo H. ^{[1
]}

Soncini, Roseli ^{[1
]}

Nascimento, Carlos Giovani O. ^{[1
]}

Giusti-Paiva, Alexandre ^{[1
]}

机构：

[1] Univ Fed Alfenas MG, Dept Ciencias Biol, Inst Biomed Sci, Physiol Lab, BR-37130000 Alfenas, MG, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2011年 / 134卷 / 02期

关键词：

Analgesia; Asteraceae; Nociception; Opioids; Pain; SENSITIVE K+ CHANNELS; DIRECT SPINAL ACTION; FORMALIN TEST; ELECTRICAL-STIMULATION; MORPHINE; INVOLVEMENT; ANALGESIA; ALKALOIDS; DRUGS; RATS;

D O I：

10.1016/j.jep.2010.12.028

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Aim of the study: Emilia sonchifolia (L.) DC. (Asteraceae) is a medicinal plant traditionally used in Brazilian folk medicine to treat asthma, fever, cuts, wounds and rheumatism. This study was conducted to establish the antinociceptive properties of hydroethanolic extract from aerial parts of Emilia sonchifolia in mice using chemical and thermal models of nociception. Materials and methods: To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used. High-performance liquid chromatography (HPLC) was used to determine the fingerprint chromatogram of the EsHE. Results: The EsHE at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract had a stronger antinociceptive effect than morphine. Administration of the opioid receptor antagonist, naloxone, completely inhibited the antinociceptive effect induced by EsHE (100 mg/kg). The presence of phenolic compounds in the extract of Emilia sonchifolia was confirmed using HPLC. Conclusion: The extract of Emilia sonchifolia markedly exhibits opioid-mediated anti-nociceptive activity action in mice. Thus, may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：348 / 353

页数：6

共 45 条

[1]

SYSTEMIC OPIOIDS DO NOT SUPPRESS SPINAL SENSITIZATION AFTER SUBCUTANEOUS FORMALIN IN RATS [J].