Highly selective chiral recognition on polymer supports:: preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

被引：61

作者：

Lewandowski, K ^{[1
]}

Murer, P ^{[1
]}

Svec, F ^{[1
]}

Fréchet, JMJ ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 20期

关键词：

D O I：

10.1039/a806395h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

引用

页码：2237 / 2238

页数：2

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