Hopping to the beat: Hop regulation of cardiac gene expression

被引：19

作者：

Kook, H ^{[1
]}

Epstein, JA ^{[1
]}

机构：

[1] Univ Penn, Hlth Syst, Div Cardiovasc, Philadelphia, PA USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S1050-1738(03)00107-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hop is a recently discovered (h) under bar omeodomain (o) under bar nly (p) under bar rotein with atypical characteristics. Unlike other homeodomain proteins, Hop lacks DNA binding activity, although it localizes predominantly to the nucleus. During embryogenesis, Hop is expressed in the myocardium of the developing heart and it functions downstream of Nkx2-5, an early cardiac-specific transcription factor. One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. This article reviews the discovery, characteristics, roles, and future perspectives of Hop. (C) 2003, Elsevier Inc.

引用

页码：261 / 264

页数：4

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