Carbon-11 acetate as a tracer of myocardial oxygen consumption

被引：75

作者：

Klein, LJ

Visser, FC

Knaapen, P

Peters, JH

Teule, GJJ

Visser, CA

Lammertsma, AA

机构：

[1] Free Univ Amsterdam Hosp, Dept Cardiol, NL-1007 MB Amsterdam, Netherlands

[2] Free Univ Amsterdam Hosp, Clin PET Ctr, NL-1007 MB Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 2001年 / 28卷 / 05期

关键词：

myocardial oxygen consumption; myocardial blood flow; carbon-11; acetate; positron emission tomography;

D O I：

10.1007/s002590000472

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

Estimation of myocardial oxygen consumption (MVO(2)) and myocardial blood flow (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, determined with positron emission tomography, allow estimation of MVO(2) on a segmental level and non-invasively. In addition, MBF can be determined from uptake rates. In this review, the background to estimation of MVO(2) and MBF is discussed, as well as the currently available literature that has used (11)C-acetate to estimate MVO(2) and MBF.

引用

页码：651 / 668

页数：18

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[2]

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[3]

REGIONAL MYOCARDIAL OXYGEN-CONSUMPTION DETERMINED NONINVASIVELY IN HUMANS WITH [1-C11]ACETATE AND DYNAMIC POSITRON TOMOGRAPHY [J].