Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats

被引：27

作者：

Kato, K

Onodera, K

Sawa, M

Imai, H

Kawahara, T

Kasai, S

Mito, M

机构：

[1] Second Department of Surgery, Asahikawa Medical College, Asahikawa 078

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 222卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.0704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The effect of human hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes was investigated. A human hepatocyte growth factor (360 mu g/kg BW) was administered intravenously every 24 hr for 5 days following hepatocyte transplantation in rats. A significant increase in hepatocyte proliferation was observed morphologically and immunohistochemically (p<0.05). The bromodexyuridine labeling index was significantly greater in human hepatocyte growth factor treated rats than in the control rats (p<0.05). Hepatocyte growth factor may promote the proliferation of intrasplenically transplanted hepatocytes. (C) 1996 Academic Press, Inc.

引用

页码：101 / 106

页数：6

共 20 条

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