Stromal Mediation of Radiation Carcinogenesis

被引：20

作者：

Barcellos-Hoff, Mary Helen ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2010年 / 15卷 / 04期

基金：

美国能源部;

关键词：

Ionizing radiation; Carcinogenesis; Stromal-epithelial interactions; Mammary gland; GROWTH-FACTOR-BETA; ATOMIC-BOMB SURVIVORS; BREAST-CANCER; IONIZING-RADIATION; INTERCELLULAR INDUCTION; CHROMOSOMAL INSTABILITY; IRRADIATED MICE; STEM-CELLS; TGF-BETA; MAMMARY;

D O I：

10.1007/s10911-010-9197-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Ionizing radiation is a well-established carcinogen in human breast and rodent mammary gland. This review addresses evidence that radiation elicits the critical stromal context for cancer, affecting not only frequency but the type of cancer. Recent data from the breast tumors of women treated with radiation therapy and the cellular mechanisms evident in experimental models suggest that radiation effects on stromal-epithelial interactions and tissue composition are a major determinant of cancer development.

引用

页码：381 / 387

页数：7

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