Magnetically actuated micromixing on an array-pattern microfluidic chip for immunoassay of human thyrotropin

被引：7

作者：

Li, CW

Wang, YN

Gao, YH ^{[1
]}

Guo, XY

Gu, ZZ

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Adv Microfabricat & Integrat Technol, Beijing 100101, Peoples R China

[2] Southeast Univ, Dept Biol Sci & Med Engn, Chien Shiung Wu Lab, Nanjing, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2005年 / 5卷 / 08期

关键词：

microfluidic chip; magnetic micromixing; high speed mixing; active mixer; immunoassay;

D O I：

10.1166/jnn.2005.211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel array-pattern ring microfluidic chip has been designed and fabricated with ITO glass, and a low-cost, easy-to-use active magnetic mixer is developed. The mixer consists of externally driven magnetic stir plates and ferromagnetic microneedles as active mobile stirrers in the microchannel. Mixing performance in the microfluidic chip has been experimentally characterized by chemiluminescence immunoassay of human thyrotropin (TSH) and compared with tube-based chemiluminescence immunoassay. The mixing method proposed in this study can be readily applied to integrated microfluidic systems, such as micro-total-analysis systems, lab-on-a-chip, and so on.

引用

页码：1297 / 1300

页数：4

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