Stress and the aging hippocampus

被引:175
作者
McEwen, BS [1 ]
机构
[1] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA
关键词
stress; hippocampal aging; glucocorticoid cascade hypothesis;
D O I
10.1006/frne.1998.0173
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The "glucocorticoid cascade hypothesis" of hippocampal aging has stimulated a great deal of research into the neuroendocrine aspects of aging and the role of glucocorticoids, in particular. Besides strengthening the methods for investigating the aging brain, this research has revealed that the interactions between glucocorticoids and hippocampal neurons are far more complicated than originally envisioned and involve the participation of neurotransmitter systems, particularly the excitatory amino acids, as well as calcium ions and neurotrophins. New information has provided insights into the role of early experience in determining individual differences in brain and body aging by setting the reactivity of the hypothalamopituitary-adrenal axis and the autonomic nervous system. As a result of this research and advances in neuroscience and the study of aging, we now have a far more sophisticated view of the interactions among genes, early development, and environmental influences, as well as a greater appreciation of events at the cellular and molecular levels which protect neurons, and a greater appreciation of pathways of neuronal damage and destruction. While documenting the ultimate vulnerability of the brain to stressful challenges and to the aging process, the net result of this research has highlighted the resilience of the brain and offered new hope for treatment strategies for promoting the health of the aging brain.
引用
收藏
页码:49 / 70
页数:22
相关论文
共 153 条
  • [1] EFFECTS OF EARLY EXPERIENCES ON EMOTIONAL AND PHYSIOLOGICAL REACTIVITY IN RAT
    ADER, R
    [J]. JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1968, 66 (02): : 264 - &
  • [2] CONSTANT CORTICOSTERONE REPLACEMENT NORMALIZES BASAL ADRENOCORTICOTROPIN (ACTH) BUT PERMITS SUSTAINED ACTH HYPERSECRETION AFTER STRESS IN ADRENALECTOMIZED RATS
    AKANA, SF
    JACOBSON, L
    CASCIO, CS
    SHINSAKO, J
    DALLMAN, MF
    [J]. ENDOCRINOLOGY, 1988, 122 (04) : 1337 - 1342
  • [3] AUSDERMUHLEN K, 1969, Z ZELLFORSCH MIK ANA, V93, P126
  • [4] HYPERCORTISOLEMIA AND HIPPOCAMPAL CHANGES IN DEPRESSION
    AXELSON, DA
    DORAISWAMY, PM
    MCDONALD, WM
    BOYKO, OB
    TUPLER, LA
    PATTERSON, LJ
    NEMEROFF, CB
    ELLINWOOD, EH
    KRISHNAN, KRR
    [J]. PSYCHIATRY RESEARCH, 1993, 47 (02) : 163 - 173
  • [5] Barbazanges A, 1996, J NEUROSCI, V16, P3943
  • [6] Barbazanges A, 1996, J NEUROSCI, V16, P7783
  • [7] Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor
    Barden, N
    Stec, ISM
    Montkowski, A
    Holsboer, F
    Reul, JMHM
    [J]. NEUROENDOCRINOLOGY, 1997, 66 (03) : 212 - 220
  • [8] CIRCADIAN-RHYTHM OF SYNAPTIC EXCITABILITY IN RAT AND MONKEY CENTRAL NERVOUS-SYSTEM
    BARNES, CA
    MCNAUGHTON, BL
    GODDARD, GV
    DOUGLAS, RM
    ADAMEC, R
    [J]. SCIENCE, 1977, 197 (4298) : 91 - 93
  • [9] STRESS-INDUCED CHANGES IN MESSENGER-RNA LEVELS OF N-METHYL-D-ASPARTATE AND AMPA RECEPTOR SUBUNITS IN SELECTED REGIONS OF THE RAT HIPPOCAMPUS AND HYPOTHALAMUS
    BARTANUSZ, V
    AUBRY, JM
    PAGLIUSI, S
    JEZOVA, D
    BAFFI, J
    KISS, JZ
    [J]. NEUROSCIENCE, 1995, 66 (02) : 247 - 252
  • [10] Neuroprotection against oxidative stress by estrogens: Structure-activity relationship
    Behl, C
    Skutella, T
    Lezoualch, F
    Post, A
    Widmann, M
    Newton, CJ
    Holsboer, F
    [J]. MOLECULAR PHARMACOLOGY, 1997, 51 (04) : 535 - 541