Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4+T-cell subsets are determined only by coreceptor expression

被引：28

作者：

Kwa, D

Vingerhoed, J

Boeser-Nunnink, B

Broersen, S

Schuitemaker, H

机构：

[1] Univ Amsterdam, Acad Med Ctr, CLB, Dept Clin Viroimmunol, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 21期

关键词：

D O I：

10.1128/JVI.75.21.10455-10459.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.

引用

收藏

页码：10455 / 10459

页数：5

相关论文

共 35 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2]

BAARS PA, 1995, J IMMUNOL, V154, P17

[3] CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo [J].

Berkowitz, RD ;

Alexander, S ;

Bare, C ;

Linquist-Stepps, V ;

Bogan, M ;

Moreno, ME ;

Gibson, L ;

Wieder, ED ;

Kosek, J ;

Stoddart, CA ;

McCune, JM .

JOURNAL OF VIROLOGY, 1998, 72 (12) :10108-10117

[4] In vivo HIV-1 infection of CD45RA+CD4+ T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4+ T cell decline [J].

Blaak, H ;

van't Wout, AB ;

Brouwer, M ;

Hooibrink, B ;

Hovenkamp, E ;

Schuitemaker, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1269-1274

[5] The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [J].

Bleul, CC ;

Wu, LJ ;

Hoxie, JA ;

Springer, TA ;

Mackay, CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1925-1930

[6] QUIESCENT LYMPHOCYTES-T AS AN INDUCIBLE VIRUS RESERVOIR IN HIV-1 INFECTION [J].

BUKRINSKY, MI ;

STANWICK, TL ;

DEMPSEY, MP ;

STEVENSON, M .

SCIENCE, 1991, 254 (5030) :423-427

[7] ACTIVE NUCLEAR IMPORT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PREINTEGRATION COMPLEXES [J].

BUKRINSKY, MI ;

SHAROVA, N ;

DEMPSEY, MP ;

STANWICK, TL ;

BUKRINSKAYA, AG ;

HAGGERTY, S ;

STEVENSON, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6580-6584

[8] The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates [J].

Choe, H ;

Farzan, M ;

Sun, Y ;

Sullivan, N ;

Rollins, B ;

Ponath, PD ;

Wu, LJ ;

Mackay, CR ;

LaRosa, G ;

Newman, W ;

Gerard, N ;

Gerard, C ;

Sodroski, J .

CELL, 1996, 85 (07) :1135-1148

[9] INCREASED VIRAL BURDEN AND CYTOPATHICITY CORRELATE TEMPORALLY WITH CD4+ T-LYMPHOCYTE DECLINE AND CLINICAL PROGRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED INDIVIDUALS [J].

CONNOR, RI ;

MOHRI, H ;

CAO, YZ ;

HO, DD .

JOURNAL OF VIROLOGY, 1993, 67 (04) :1772-1777

[10] THE CD27- SUBSET OF PERIPHERAL-BLOOD MEMORY CD4+ LYMPHOCYTES CONTAINS FUNCTIONALLY DIFFERENTIATED LYMPHOCYTES-T THAT DEVELOP BY PERSISTENT ANTIGENIC-STIMULATION INVIVO [J].

DEJONG, R ;

BROUWER, M ;

HOOIBRINK, B ;

VANDERPOUWKRAAN, T ;

MIEDEMA, F ;

VANLIER, RAW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (04) :993-999

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