Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice

被引：65

作者：

Hiroshima, Yukihiko ^{[1
,2
,3
]}

Zhao, Ming ^{[1
]}

Zhang, Yong ^{[1
]}

Zhang, Nan ^{[1
]}

Maawy, Ali ^{[2
]}

Murakami, Takashi ^{[1
,2
,3
]}

Mii, Sumiyuki ^{[1
,2
]}

Uehara, Fuminari ^{[1
,2
]}

Yamamoto, Mako ^{[1
,2
]}

Miwa, Shinji ^{[1
,2
]}

Yano, Shuya ^{[1
,2
]}

Momiyama, Masashi ^{[3
]}

Mori, Ryutaro ^{[3
]}

Matsuyama, Ryusei ^{[3
]}

Chishima, Takashi ^{[3
]}

Tanaka, Kuniya ^{[3
]}

Ichikawa, Yasushi ^{[3
]}

Bouvet, Michael ^{[2
]}

Endo, Itaru ^{[3
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] AntiCancer Inc, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[3] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Yokohama, Kanagawa 232, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 08期

关键词：

HUMAN PANCREATIC-CANCER; LUNG METASTASIS; MOUSE MODEL; EFFICACY; CHEMOTHERAPY; THERAPY; MUTANT; CELLS; CYCLE;

D O I：

10.1371/journal.pone.0134324

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A patient-derived nude-mouse model of soft-tissue sarcoma has been established and treated in the following groups: (1) untreated controls; (2) gemcitabine (GEM) (80 mg/kg, ip, weekly, 3 weeks); (3) Pazopanib (100 mg/kg, orally, daily, 3 weeks) and (4) Salmonella typhimurium A1-R (5 x 10(7) CFU/body, ip, weekly, 3 weeks). The sarcoma was resistant to GEM (p = 0.879). Pazopanib tended to reduce the tumor volume compared to the untreated mice, but there was no significant difference (p = 0.115). S. typhimurium A1-R significantly inhibited tumor growth compared to the untreated mice (p = 0.001). S. typhimurium A1-R was the only effective treatment for the soft-tissue sarcoma nude mouse model among all treatments including a newly approved multiple tyrosine kinase inhibitor; Pazopanib. These results suggest tumor-targeting S. typhimurium A1-R is a promising treatment for chemo-resistant soft-tissue sarcoma.

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页数：9

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