Efficient alkali iodide promoted 18F-fluoroethylations with 2-[18F]fluoroethyl tosylate and 1-bromo-2-[18F]fluoroethane

被引：33

作者：

Bauman, A ^{[1
]}

Piel, M ^{[1
]}

Schirrmacher, R ^{[1
]}

Rösch, F ^{[1
]}

机构：

[1] Univ Mainz, Inst Nucl Chem, D-55128 Mainz, Germany

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 51期

关键词：

positron emission tomography; F-18-fluoroethylation; 2-[F-18]fluoroethyl tosylate; 1-bromo-2-[F-18]fluoroethane;

D O I：

10.1016/j.tetlet.2003.10.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radiochemical F-18-fluorination yields of several compounds using the secondary labelling precursors 2-[F-18]fluoroethyl tosylate ([(18)]FETos) and 1-bromo-2-[F-18]fluoroethane ([F-18]BFE) could be considerably enhanced by the addition of an alkali iodide. The radiochemical yield of [F-18]fluoroethyl choline for example could be doubled with [F-18]BFE and increased from 13% to approximate to80% with [F-18]FETos. By addition of alkali iodide to the precursor, the F-18-fluoroethylation yields of established radiopharmaceuticals, especially in the case of automated syntheses, could be significantly increased without major changes of the reaction conditions. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9165 / 9167

页数：3

共 9 条

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